Daiichi Sankyo and AstraZeneca Report CHMP Positive Opinion for Enhertu + Perjeta to Treat HER2-Positive Metastatic Breast Cancer

Shots: The CHMP has recommended Enhertu (5.4mg/kg) + Perjeta for the 1L treatment of pts with HER2+ unresectable or metastatic breast cancer (MBC), backed by P-III (DESTINY-Breast09) trial data (n=1157) Trial assessed Enhertu ± Perjeta vs THP, where it improved PFS by 44% in 383 pts who had not received prior CT or HER2-targeted therapy, or had received neoadj./adj. HER2-targeted therapy for >6mos. before advanced/metastatic disease diagnosis mPFS was 40.7 vs 26.9mos., with consistent benefit across HR status, de novo/recurrent disease, & PIK3CA mutation subgroups. cORR was 85.1% vs 78.6%, incl. 58 vs 33 CRs & 268 vs 271 PRs, while mDOR was 39.2 vs 26.4mos. Data were published in THE NEJM Ref: Businesswire  | Image: Daiichi Sankyo& AstraZeneca |   Press Release PharmaShots, your go-to media platform for customized news ranging across multiple indications. For more information, connect with us at connect@pharmashots.com The post Daiichi Sankyo and AstraZeneca Report CHMP Positive Opinion for Enhertu + Perjeta to Treat HER2-Positive Metastatic Breast Cancer appeared first on PharmaShots.