Dyne Therapeutics Reports IND Clearance to Initiate P-I Trial of  DYNE-302 for FSHD

Shots: The US FDA has granted IND clearance to initiate a P-I multiple ascending dose trial assessing DYNE-302 against PBO in ambulatory adults with facioscapulohumeral muscular dystrophy (FSHD) In the first cohort, 9 pts will receive DYNE-302 (1.5 mg/kg, Q4W) or PBO, with higher doses & less frequent dosing planned. Pts completing the PBO-controlled phase may enter a 96wk. OLE study In preclinical FSHD models, DYNE-302 achieved robust DUX4 transcriptome knockdown in skeletal muscle, significantly reversed muscle fibre damage, & improved muscle function Ref: Globenewswire  | Image:  Dyne Therapeutics  |   Press Release PharmaShots, your go-to media platform for customized news ranging across multiple indications. For more information, connect with us at connect@pharmashots.com The post Dyne Therapeutics Reports IND Clearance to Initiate P-I Trial of  DYNE-302 for FSHD appeared first on PharmaShots.