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Insilico Medicine Advances AI-Designed IPF Drug Rentosertib into P-III Trial

Jul 8, 2026, 11:30 AM

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Shots: Insilico has initiated a P-III trial assessing Rentosertib vs PBO in ~320 pts with idiopathic pulmonary fibrosis (IPF) over 52wks. Earlier P-IIa (GENESIS-IPF) trial data showed Rentosertib (30mg, QD or BID, & 60mg, QD) met its 1EP, plus 60mg arm demonstrated a mean FVC change of +98.4mL vs -20.3mL at 12wks. Rentosertib, an oral small-molecule inhibitor targeting TNIK, was discovered using Insilico’s Pharma.AI platform, with PandaOmics identifying the novel TNIK target and Chemistry42 designing the small molecule Ref: PRnewswire | Image: Insilico Medicine | Press Release Related News: Insilico Medicine Collaborates with Takeda to Advance AI Drug Discovery PharmaShots, your go-to media platform for customized news ranging across multiple indications. For more information, connect with us at connect@pharmashots.com The post Insilico Medicine Advances AI-Designed IPF Drug Rentosertib into P-III Trial appeared first on PharmaShots.